Frankie Pamplemousse, an energetic 8-year-old girl, lives in Anytown with her four talking, extraordinary hamsters; Pipsqueak, Mr. Squiggles, Num Nums, and Chunk.
Frankie and the Zhus try to make Ellen and Stanley's anniversary a blast by planning their own.
The Zhus get stuck in the wild after a skunk shows up in their house.
After Frankie's baseball glove is accidentally left at home, the Zhus try to return it back to her before her big game starts.
Ellen tells the Zhus that they can't go to the grocery store, but they break the rule after Chunk eats all of the chocolate chips.
While getting her dog Walter a snack, Frankie asks the Zhus to dog-sit him. But they accidentally let Walter out the backyard.
The Zhus try to make friends with Mr. Kerdle, while Frankie tries to stop them from getting in trouble.
Frankie is told she can't plumb with her parents on a level 5 job for professionals only. When the Zhus give Frankie something to do, a pipe snaps and the entire house floods.
Frankie is offered a deal to appear on television to show off her skateboarding skills, but Chunk gets carried away when giving her a makeover.
Frankie and the Zhus think that the Gelato twins have turned into zombies after watching a zombie film during a sleepover.
Frankie is sick and can't go to the Go-Kart race, so the Zhus try to help her get better in time.
Num Nums gets taken by Madge's cat, so the Zhus try to rescue her while Frankie distracts Madge.
Frankie and the Zhus try to get on a TV show called World's Funniest Pets.
A rainy day prevents the Zhus from doing the Iron Hamster Games, until Frankie decides to do it inside.
Frankie and the Zhus pretend to be superheroes, but Mr. Squiggles takes his role as the villain too seriously.
Frankie and the Zhus take care of a baby bird and teach it to fly.
When Frankie gets two friendship bracelets from her aunt Zia, the Zhus compete to see who is Frankie's best friend.
Frankie's parents get an emergency plumbing call from Frankie's favorite popstar Jessica Beeker. They take Frankie and the Zhus with them to meet Jessica, but Frankie becomes nervous.
Frankie and the Zhus try to help Ellen get her last Power Badge Girls badge, the camping badge, when they learn she's afraid of the dark.
The Zhus help Frankie decide what she wants to be when she grows up for a school project.
When Frankie breaks her fourth skateboard, her parents cut a deal that she can get another if she goes a week without breaking an egg.
Chunk accidentally uses Frankie's present for Ellen as a letter for the Rainbow Roo.
The lamp is broken and Frankie and the Zhus each tell Ellen their stories of what happened.
The Zhus try to stop Frankie from dancing in the school talent show after seeing her moves.
Frankie gives the Zhus their first vacation experience by running a hotel in the backyard.
Frankie and the Zhus stay up for the New Years without sleeping.
Frankie's desires for another treasure hunt are ruined, so Mr. Squiggles hides a cookie jar which has Frankie's parents' tickets in it. But he forgets where he hid it.
Frankie signs up for the annual Biggest Pumpkin Growing contest and competes with Madge.
Frankie plays Zhuper Girl again, and the Zhus try to show who is sidekick worthy.
Mr. Squiggles tests the new Hamster Cannon 3000 by blasting Chunk into the sky. When he comes back, he is mistaken for an alien.
Chunk develops a fear of spiders after getting tangled in a spider web.
Frankie wants to be an author. So she tries to write a book, but she develops writer's block. The Zhus help her write the book by living the experience in real life.
Frankie gets a new haircut, which is the same as Ellen's. She doesn't like it, so the Zhus try to make it better.
Frankie and the Zhus create their own emergency kit to prepare for a thunderstorm.
Frankie and the Zhus play Zhuper Girl again to help the park throw out garbage, but Madge tricks the town by impersonating Frankie.
Frankie and the Zhus are inspired to make cave paintings after watching a film about caves in school.
After learning that Madge has won the annual go-kart race every year, Frankie and the Zhus enter the go-kart race so they can break Madge's winning streak.
After overhearing the family's concerns with his inventions, Mr. Squiggles decides to quit science and become a surfer.
Frankie and the Zhus try to avoid having an unlucky day after a fortune cookie tells them that they will have one.
After seeing the Amazing Donald's magic show, Frankie tries to make Chunk invisible. But he falls into a hamster tube and runs around town, thinking the trick had worked.
Frankie realizes she's too big to enjoy some of the games her and the Zhus play, so she dreams about being small.
Frankie's board game transforms her house into a castle.
Frankie nominates the Zhus in her own awards show after learning that they've never won a trophy.
When the Zhus are ordered to take care of Chunk's cousins Jilly and Bean, the Zhus must make sure they don't ruin Frankie's fancy party.
While preparing for her next baseball tournament at the baseball stadium tomorrow, Frankie plays in the house, causing her baseball to be taken away for a week, and the Zhus to face this.
Ever since every commercial they find boring has relieved on them for 24 whole hours, Frankie and the Zhus work on their own commercials to beat the ad record.
Zhuper Girl solves a crime again, But this time, her new archenemy gets back at her for saving the day.
In a story about Goldilocks and The Three Bears, Frankie and the Zhus start a play about themselves in the story.
Num Nums makes a new quilt, and the other Zhus ruin accidentally wreck it. She quits being herself and refuses to help them when they are in danger.
Tired of Frankie's parents being in charge all the time, Frankie and the Zhus make up their own house rules.
Frankie and the Zhus are sent to Zhu Land to reunite the band The Zhu-riff-ics back together.
