Dr. Pontianak is about Dr. Vivy, a 26-year-old medical trainee who wakes up one day with injuries and a nail behind her neck. Strangely, she develops a craving for blood instead of fearing it.
Dr. Vivy wakes up in a drain and is stunned by what she discovers. Not only can she suddenly see Edna, the hospital ghost, but she also finds a mysterious nail embedded in her neck.
Edna brings Dr. Vivy to Pak Us, a shaman who reveals that she is a 'Ponti-no-anak' after witnessing her transformation into a frightening supernatural being.
When Dr. Vivy begins freezing up unexpectedly, Dr. Adam and Dr. John suspect she may be using drugs. Meanwhile, Edna and Pak Us race to uncover the cause of her mysterious symptoms.
When Mr. Rumi is stabbed outside the hospital, Dr. Vivy is the first to find him. But the real shock comes when she sees his spirit lingering nearby, determined to tell her who tried to kill him.
Edna falls in love with Mr. Wayan Rayan's Hantu Raya and is convinced that he is the one for her. She is determined to marry and look after the supernatural being. Meanwhile, Dr. Vivy develops an unusually powerful sense of smell.
The mysterious death of Jane's grandmother leaves the hospital staff searching for answers. Meanwhile, Edna's dreams of marriage are crushed when she comes face-to-face with the Hantu Raya's true appearance.
After the hospital is placed under spiritual barrier, Edna finds herself unable to enter the premises. As she befriends a mischievous toyol, a mysterious series of missing blood bags begins to trouble the hospital.
Edna and Dr. Vivy set out to capture a toyol that is roaming Kechik Mega Utara Hospital, hoping to uncover who has been draining blood from the ward’s patients.
The death of a patient named Hana deepens the mystery in the ward after she confides in Dr. Vivy that someone inserted a fetus into her womb.
Edna and Dr. Vivy succeed in returning BabyTo to its rightful owner. However, they discover a new lead after coming across a lorry driver who had thrown Dr. Vivy into the river.
Dr. Adam’s blood theft case has finally reached Dr. Ghani. At the same time, Dr. Vivy discovers she can now float, and with Edna’s help, she struggles to control her new ability.
It is revealed that Dr. Ghani has known about Edna’s presence at Kechik Mega Utara Hospital all along, and that he is connected to the mystery of the missing blood bags.
